Publication Date:
1990-01-26
Description:
Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Henthorn, P -- Kiledjian, M -- Kadesch, T -- New York, N.Y. -- Science. 1990 Jan 26;247(4941):467-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Philadelphia, PA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2105528" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/metabolism
;
Base Sequence
;
Binding Sites
;
Cell Line
;
Cloning, Molecular
;
DNA/genetics/*metabolism
;
*Enhancer Elements, Genetic
;
*Genes, Immunoglobulin
;
Humans
;
Immunoglobulin kappa-Chains/genetics
;
Immunoglobulin mu-Chains/genetics
;
Macromolecular Substances
;
Mice
;
Molecular Sequence Data
;
Plasmids
;
Protein Conformation
;
Saccharomyces cerevisiae/genetics
;
Transcription Factors/*metabolism
;
Transcription, Genetic
;
Transfection
;
Transformation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
