Publication Date:
1991-04-05
Description:
Calcium salts are strong taste stimuli in vertebrate animals. However, the chemosensory transduction mechanisms for calcium are not known. In taste buds of Necturus maculosus (mud puppy), calcium evokes depolarizing receptor potentials by acting extracellularly on the apical ends of taste cells to block a resting potassium conductance. Therefore, divalent cations elicit receptor potentials in taste cells by modulating a potassium conductance rather than by permeating the cell membrane, the mechanism utilized by monovalent cations such as sodium and potassium ions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bigiani, A R -- Roper, S D -- 2 POI NS 20486/NS/NINDS NIH HHS/ -- 2 RO1 NS24107/NS/NINDS NIH HHS/ -- 5 RO1 AG06557/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1991 Apr 5;252(5002):126-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, Colorado State University, Fort Collins 80523.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2011748" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cadmium/pharmacology
;
Calcium/*physiology
;
Electric Conductivity
;
In Vitro Techniques
;
Membrane Potentials
;
Necturus
;
Potassium/*physiology
;
Potassium Channels/*physiology
;
Taste/*physiology
;
Tetraethylammonium Compounds/pharmacology
;
Tongue/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
