Publication Date:
1991-03-22
Description:
Cadherins are a family of cell adhesion receptors that are crucial for the mutual association of vertebrate cells. Through their homophilic binding interactions, cadherins play a role in cell-sorting mechanisms, conferring adhesion specificities on cells. The regulated expression of cadherins also controls cell polarity and tissue morphology. Cadherins are thus considered to be important regulators of morphogenesis. Moreover, pathological examinations suggest that the down-regulation of cadherin expression is associated with the invasiveness of tumor cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Takeichi, M -- New York, N.Y. -- Science. 1991 Mar 22;251(5000):1451-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biophysics, Faculty of Science, Kyoto University, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2006419" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/pathology
;
Animals
;
Cadherins/*physiology
;
Calcium/physiology
;
*Cell Adhesion
;
Cytoskeleton/physiology
;
Humans
;
*Morphogenesis
;
Neoplasm Metastasis
;
Stomach Neoplasms/pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
