Publication Date:
1990-06-15
Description:
During development in the thymus, T cells are rendered tolerant to self antigens. It is now apparent that thymocytes bearing self-reactive T cell receptors can be tolerized by processes that result in physical elimination (clonal deletion) or functional inactivation (clonal anergy). As these mechanisms have important clinical implications for transplantation and autoimmunity, current investigations are focused on understanding the cellular and molecular interactions that generate these forms of tolerance.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramsdell, F -- Fowlkes, B J -- New York, N.Y. -- Science. 1990 Jun 15;248(4961):1342-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1972593" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Surface/immunology
;
Autoantigens/immunology
;
Autoimmunity/immunology
;
Bone Marrow/immunology
;
CD4-Positive T-Lymphocytes/immunology
;
Chickens
;
Chimera
;
Clone Cells/*immunology
;
H-2 Antigens/immunology
;
Histocompatibility Antigens/immunology
;
Histocompatibility Antigens Class II/immunology
;
*Immune Tolerance
;
Mice
;
Mice, Transgenic
;
Minor Lymphocyte Stimulatory Antigens
;
Receptors, Antigen, T-Cell/*immunology
;
T-Lymphocytes/*immunology
;
T-Lymphocytes, Regulatory/immunology
;
Thymus Gland/*immunology
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
