Publication Date:
1991-08-23
Description:
The evolutionary significance of protein polymorphisms has long been debated. Exponents of the balanced theory advocate that selection operates to maintain polymorphisms, whereas the neoclassical school argues that most genetic variation is neutral. Some studies have suggested that protein polymorphisms are not neutral, but their significance has been questioned because one cannot eliminate the possibility that linked loci were responsible for the observed differences. Evidence is presented that an enzymatic phenotype can affect carbon flow through a metabolic pathway. Glucose flux differences between lactate dehydrogenase-B phenotypes of Fundulus heteroclitus were reversed by substituting the Ldh-B gene product of one homozygous genotype with that of another.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉DiMichele, L -- Paynter, K T -- Powers, D A -- New York, N.Y. -- Science. 1991 Aug 23;253(5022):898-900.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Wildlife and Fisheries Sciences, Texas A&M University, College Station 77843.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1876847" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blastocyst/enzymology
;
Genotype
;
Glucose/metabolism
;
Glycolysis
;
Isoenzymes
;
Killifishes/embryology/*genetics/metabolism
;
Kinetics
;
L-Lactate Dehydrogenase/*genetics/metabolism
;
Lactates/metabolism
;
Lactic Acid
;
Microinjections
;
Phenotype
;
Swine
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
