Publication Date:
1991-07-12
Description:
The removal of introns from eukaryotic messenger RNA precursors shares mechanistic characteristics with the self-splicing of certain introns, prompting speculation that the catalytic reactions of nuclear pre-messenger RNA splicing are fundamentally RNA-based. The participation of five small nuclear RNAs (snRNAs) in splicing is now well documented. Genetic analysis in yeast has revealed the requirement, in addition, for several dozen proteins. Some of these are tightly bound to snRNAs to form small nuclear ribonucleoproteins (snRNPs); such proteins may promote interactions between snRNAs or between an snRNA and the intron. Other, non-snRNP proteins appear to associate transiently with the spliceosome. Some of these factors, which include RNA-dependent adenosine triphosphatases, may promote the accurate recognition of introns.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Guthrie, C -- GM21119/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1991 Jul 12;253(5016):157-63.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1853200" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/physiology
;
Base Sequence
;
Fungal Proteins/genetics
;
Molecular Sequence Data
;
*RNA Splicing
;
RNA, Fungal/*genetics
;
RNA, Messenger/*genetics
;
RNA, Small Nuclear/genetics
;
Ribonucleoproteins/*physiology
;
Saccharomyces cerevisiae/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
