Publication Date:
1991-05-10
Description:
In order to identify genes specific for the sensory neurons of Aplysia, a miniaturized differential screening method based on the polymerase chain reaction and applicable to small amounts of tissue was used. One messenger RNA was isolated that is expressed in every mechanoreceptor sensory cluster of the Aplysia central nervous system. This messenger RNA encodes a peptide that seems to function as an inhibitory cotransmitter. The peptide selectively inhibits certain postsynaptic cells but not others and thereby allows the sensory neurons to achieve target-specific synaptic actions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brunet, J F -- Shapiro, E -- Foster, S A -- Kandel, E R -- Iino, Y -- New York, N.Y. -- Science. 1991 May 10;252(5007):856-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, New York, NY.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1840700" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Aplysia
;
Biomarkers
;
Blotting, Northern
;
Chromatography, High Pressure Liquid
;
In Vitro Techniques
;
Neurons, Afferent/*chemistry
;
Nucleic Acid Hybridization
;
Peptides/*analysis
;
Polymerase Chain Reaction
;
RNA, Messenger/analysis
;
Species Specificity
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
