Publikationsdatum:
1991-10-25
Beschreibung:
After antigenic stimulation of T lymphocytes, genes essential for proliferation and immune function, such as the interleukin-2 (IL-2) gene, are transcriptionally activated. In both transient transfections and T lymphocyte-specific in vitro transcription, the homeodomain-containing protein Oct-1 participated in the inducible regulation of transcription of the IL-2 gene. Oct-1 functioned in this context with a 40-kilodalton protein called Oct-1-associated protein (OAP40). In addition to interacting specifically with DNA, OAP40 reduced the rate of dissociation of Oct-1 from its cognate DNA-binding site, suggesting that a direct interaction exists between Oct-1 and OAP40.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ullman, K S -- Flanagan, W M -- Edwards, C A -- Crabtree, G R -- AI07290/AI/NIAID NIH HHS/ -- CA39612/CA/NCI NIH HHS/ -- HL33942/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1991 Oct 25;254(5031):558-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Stanford University, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1683003" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Amino Acid Sequence
;
Animals
;
Antibodies, Monoclonal
;
Base Sequence
;
DNA-Binding Proteins/biosynthesis/*genetics/*physiology
;
Enhancer Elements, Genetic
;
*Gene Expression Regulation
;
Genes, Homeobox
;
Host Cell Factor C1
;
Interleukin-2/*genetics
;
Mice
;
Mice, Inbred BALB C/immunology
;
Molecular Sequence Data
;
Octamer Transcription Factor-1
;
Oligodeoxyribonucleotides
;
Peptides/chemical synthesis/immunology
;
Rats
;
T-Lymphocytes/immunology/*physiology
;
Transcription Factors/*genetics/physiology
;
*Transcription, Genetic
;
Transfection
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
