Publication Date:
1992-12-11
Description:
The telomeres of Xq and Yq have been observed to associate during meiosis, and in rare cases a short synaptonemal complex is present. Molecular cloning of loci from Xqter and Yqter has revealed that their sequence homology extends over 400 kilobases, which suggests the possibility of genetic exchange. This hypothesis was tested by the development of two highly informative microsatellite markers from yeast artificial chromosome clones that carried Xqter sequences and the following of their inheritance in a set of reference pedigrees from the Centre d'Etude du Polymorphisme Humain in Paris, France. From a total of 195 informative male meioses, four recombination events between these loci were observed. In three cases, paternal X alleles were inherited by male offspring, and in one case a female offspring inherited her father's Y allele. These data support the existence of genetic exchange at Xq-Yq, which defines a second pseudoautosomal region between the sex chromosomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freije, D -- Helms, C -- Watson, M S -- Donis-Keller, H -- HG00100/HG/NHGRI NIH HHS/ -- HG00201/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 1992 Dec 11;258(5089):1784-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1465614" target="_blank"〉PubMed〈/a〉
Keywords:
Alleles
;
Animals
;
Base Sequence
;
Cell Line
;
Chromosome Banding
;
Chromosome Mapping
;
Chromosomes, Fungal
;
Cloning, Molecular
;
DNA/*genetics
;
Factor VIII/genetics
;
Female
;
Gene Conversion
;
Genetic Linkage
;
Haplotypes
;
Humans
;
Hybrid Cells
;
Male
;
Molecular Sequence Data
;
Oligodeoxyribonucleotides
;
Pedigree
;
Polymerase Chain Reaction/methods
;
Recombination, Genetic
;
Rodentia
;
Saccharomyces cerevisiae/genetics
;
Sequence Homology, Nucleic Acid
;
Telomere/*physiology/ultrastructure
;
*X Chromosome
;
*Y Chromosome
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
