Publication Date:
1992-08-21
Description:
T cells of the immune system respond only to foreign antigens because those cells with reactivity for self proteins are either deleted during their development or rendered nonresponsive (anergic). The maintenance of the nonresponsive state was found to require the continual exposure of the anergic T cells to antigen. When anergic T cells were removed from the self antigen by adoptive transfer to a mouse strain lacking the antigen or by in vitro culture, nonresponsiveness was reversed and the anergic cells returned to normal functional status.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramsdell, F -- Fowlkes, B J -- New York, N.Y. -- Science. 1992 Aug 21;257(5073):1130-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1354889" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antibodies, Monoclonal/immunology
;
Autoantigens/*immunology
;
Bone Marrow Transplantation
;
CD4-Positive T-Lymphocytes/immunology
;
*Immune Tolerance
;
Lymph Nodes/cytology/immunology/transplantation
;
Mice
;
Mice, Inbred AKR
;
Minor Lymphocyte Stimulatory Antigens/immunology
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocytes/*immunology
;
T-Lymphocytes, Regulatory/immunology
;
Whole-Body Irradiation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
