Publication Date:
1992-02-28
Description:
The transcription factor E2F controls the expression of several proliferation-related genes and is a target of the adenovirus E1A oncogene. In human cells, both cyclin A and the cdk2 protein kinase were found in complexes with E2F. Although the total amounts of cdk2 were constant in the cell cycle, binding to E2F was detected only when cells entered S phase, a time when the cdk2 kinase is activated. These data suggest that the interaction between cdk2 and E2F requires an active kinase that has cyclin A as a targeting component.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pagano, M -- Draetta, G -- Jansen-Durr, P -- New York, N.Y. -- Science. 1992 Feb 28;255(5048):1144-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉European Molecular Biology Laboratory, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1312258" target="_blank"〉PubMed〈/a〉
Keywords:
Adenovirus Early Proteins
;
Base Sequence
;
*CDC2-CDC28 Kinases
;
*Carrier Proteins
;
Cell Cycle
;
*Cell Cycle Proteins
;
Cyclin-Dependent Kinase 2
;
*Cyclin-Dependent Kinases
;
Cyclins/*metabolism
;
*DNA-Binding Proteins
;
E2F Transcription Factors
;
HeLa Cells
;
Humans
;
Macromolecular Substances
;
Molecular Sequence Data
;
Oligodeoxyribonucleotides/chemistry
;
Oncogene Proteins, Viral/genetics
;
Protamine Kinase/metabolism
;
Protein Kinases/*metabolism
;
*Protein-Serine-Threonine Kinases
;
Retinoblastoma-Binding Protein 1
;
*S Phase
;
Transcription Factor DP1
;
Transcription Factors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
