Publication Date:
2000-11-18
Description:
T cell memory depends on factors that regulate expansion and death of these cells after antigenic stimulation. Mice deficient in perforin and interferon-gamma (IFN-gamma) exhibited increased expansion, altered immunodominance, and decreased death of antigen-specific CD8+ T cells after infection with an attenuated strain of Listeria monocytogenes, which was cleared from these mice. Expansion of CD8+ T cells was controlled by perforin, whereas IFN-gamma regulated immunodominance and the death phase. Thus, perforin and IFN-gamma regulate distinct elements of CD8+ T cell homeostasis independently of their role as antimicrobial effector molecules.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Badovinac, V P -- Tvinnereim, A R -- Harty, J T -- AI36864/AI/NIAID NIH HHS/ -- AI42767/AI/NIAID NIH HHS/ -- T32AI07511/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 2000 Nov 17;290(5495):1354-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52242, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11082062" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigen-Presenting Cells/immunology
;
Antigens, Bacterial/immunology
;
Apoptosis
;
CD8-Positive T-Lymphocytes/cytology/*immunology
;
Homeostasis
;
Immunodominant Epitopes/*immunology
;
*Immunologic Memory
;
Interferon-gamma/*physiology
;
Listeria monocytogenes/immunology
;
Listeriosis/*immunology
;
Lymphocytic Choriomeningitis/immunology
;
Membrane Glycoproteins/*physiology
;
Mice
;
Mice, Inbred BALB C
;
Mice, Knockout
;
Perforin
;
Pore Forming Cytotoxic Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
