Publication Date:
2000-08-19
Description:
Members of the seven transmembrane receptor superfamily bind a remarkable variety of ligands, from neurotransmitters to odorants, and activate a spectacular array of G protein signaling molecules. These G-protein coupled receptors (GPCRs) are important in many cellular functions and so there has been great interest in elucidating how they transmit their signals to the interior of the cell after activation by ligand. As Bourne and Meng explain in their Perspective, the molecular movements of activated GPCRs are becoming clear now that the first crystal structure of a GPCR (rhodopsin, the light-trapping receptor found in the retina of the eye) has been reported (Palczweski et al.).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bourne, H R -- Meng, E C -- New York, N.Y. -- Science. 2000 Aug 4;289(5480):733-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA. bourne@cmp.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10950717" target="_blank"〉PubMed〈/a〉
Keywords:
Binding Sites
;
Crystallography, X-Ray
;
Evolution, Molecular
;
Heterotrimeric GTP-Binding Proteins/metabolism
;
Ligands
;
Lipid Bilayers
;
Models, Molecular
;
Protein Structure, Secondary
;
Receptors, Cell Surface/chemistry/metabolism
;
Retinaldehyde/metabolism
;
Rhodopsin/*chemistry/metabolism
;
Stereoisomerism
;
Vision, Ocular
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
