Publication Date:
2000-08-12
Description:
The life-span of sperm may be short but it is certainly busy. The three principal molecular events that prepare sperm for fertilization are all controlled by the intracellular nucleotide adenosine 3',5'-monophosphate (cAMP). One of these, capacitation, is also regulated by bicarbonate ions. The elusive connection between cAMP and bicarbonate ions now appears to be solved as Kaupp and Weyand explain in their Perspective. Bicarbonate ions enter sperm through the anion transporter in the sperm plasma membrane and activate the soluble form of adenylyl cyclase, the enzyme that synthesizes cAMP (Chen et al.)〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaupp, U B -- Weyand, I -- New York, N.Y. -- Science. 2000 Jul 28;289(5479):559-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biologische Informationsverarbeitung, Forschungszentrum Jlich, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10939966" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/chemistry/*metabolism
;
Animals
;
Bicarbonates/*metabolism/pharmacology
;
Calcium Channels/metabolism
;
Catalytic Domain
;
Cyclic AMP/*metabolism
;
Cyclic Nucleotide-Gated Cation Channels
;
Enzyme Activation
;
Humans
;
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
;
Ion Channels/metabolism
;
Male
;
Molecular Weight
;
*Muscle Proteins
;
Potassium Channels
;
Rats
;
Signal Transduction
;
Solubility
;
*Sperm Capacitation
;
Sperm Motility
;
Sperm Tail/physiology
;
Spermatozoa/metabolism/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
