Publication Date:
2000-07-15
Description:
Bone morphogenetic proteins (BMPs) have multiple functions in the developing nervous system. A member of this family, BMP-9, was found to be highly expressed in the embryonic mouse septum and spinal cord, indicating a possible role in regulating the cholinergic phenotype. In cultured neurons, BMP-9 directly induced the expression of the cholinergic gene locus encoding choline acetyltransferase and the vesicular acetylcholine transporter and up-regulated acetylcholine synthesis. The effect was reversed upon withdrawal of BMP-9. Intracerebroventricular injection of BMP-9 increased acetylcholine levels in vivo. Although certain other BMPs also up-regulated the cholinergic phenotype in vitro, they were less effective than BMP-9. These data indicate that BMP-9 is a differentiating factor for cholinergic central nervous system neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lopez-Coviella, I -- Berse, B -- Krauss, R -- Thies, R S -- Blusztajn, J K -- P01 AG09525/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):313-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10894782" target="_blank"〉PubMed〈/a〉
Keywords:
Acetylcholine/biosynthesis
;
Animals
;
Bone Morphogenetic Proteins/*physiology
;
Carrier Proteins/genetics
;
Cells, Cultured
;
Central Nervous System
;
Choline O-Acetyltransferase/genetics
;
Embryo, Mammalian/metabolism
;
Fibroblast Growth Factor 2/physiology
;
Gene Expression Regulation, Developmental
;
Gene Expression Regulation, Enzymologic
;
Growth Differentiation Factor 2
;
*Membrane Transport Proteins
;
Mice
;
Neurons/metabolism
;
Phenotype
;
RNA, Messenger/metabolism
;
Septum of Brain/embryology/metabolism
;
Spinal Cord/embryology/metabolism
;
Up-Regulation
;
Vesicular Acetylcholine Transport Proteins
;
*Vesicular Transport Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
