Publication Date:
2000-07-15
Description:
The spindle checkpoint was characterized in meiosis of budding yeast. In the absence of the checkpoint, the frequency of meiosis I missegregation increased with increasing chromosome length, reaching 19% for the longest chromosome. Meiosis I nondisjunction in spindle checkpoint mutants could be prevented by delaying the onset of anaphase. In a recombination-defective mutant (spo11Delta), the checkpoint delays the biochemical events of anaphase I, suggesting that chromosomes that are attached to microtubules but are not under tension can activate the spindle checkpoint. Spindle checkpoint mutants reduce the accuracy of chromosome segregation in meiosis I much more than that in meiosis II, suggesting that checkpoint defects may contribute to Down syndrome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Shonn, M A -- McCarroll, R -- Murray, A W -- New York, N.Y. -- Science. 2000 Jul 14;289(5477):300-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10894778" target="_blank"〉PubMed〈/a〉
Keywords:
Biomechanical Phenomena
;
Chromosome Segregation/*physiology
;
Chromosomes, Fungal
;
Down Syndrome/genetics
;
Endodeoxyribonucleases
;
Esterases/genetics
;
Kinetochores/physiology
;
Meiosis/genetics/*physiology
;
Mutation
;
Nondisjunction, Genetic
;
Recombination, Genetic
;
Saccharomycetales/genetics/*physiology
;
Spindle Apparatus/*physiology
;
Spores, Fungal
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
