Publication Date:
1999-09-18
Description:
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malenka, R C -- Nicoll, R A -- New York, N.Y. -- Science. 1999 Sep 17;285(5435):1870-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA. malenka@stanford.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10489359" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium Signaling
;
Hippocampus/*physiology
;
Humans
;
Long-Term Potentiation/*physiology
;
Models, Neurological
;
Protein Kinases/metabolism
;
Pyramidal Cells/physiology
;
Receptors, AMPA/metabolism
;
Receptors, N-Methyl-D-Aspartate/physiology
;
Synapses/*physiology
;
Synaptic Transmission/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
