Publication Date:
1999-07-27
Description:
The critical role of cellular immunity in resistance to infectious diseases is glaringly revealed by life-threatening infections if T cell function is disrupted by an inherited or acquired immunodeficiency. Although treatment has historically focused on infectious complications, understanding of the cellular and molecular basis of immunodeficiency and technologies useful for enhancing cellular immunity have both been rapidly evolving. A new era of molecular and cellular therapy is emerging as approaches to correct abnormal genes, the loss of T cell subpopulations, and aberrant T cell homeostasis make the transition from bench to bedside.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenberg, P D -- Riddell, S R -- AI27757/AI/NIAID NIH HHS/ -- AI41754/AI/NIAID NIH HHS/ -- CA33084/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1999 Jul 23;285(5427):546-51.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fred Hutchinson Cancer Research Center and Departments of Medicine and Immunology, University of Washington, Seattle, WA 98195, USA. pgreen@u.washington.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10417377" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
Anti-HIV Agents/therapeutic use
;
HIV Infections/*immunology/therapy
;
Hematopoietic Stem Cell Transplantation
;
Humans
;
Immunity, Cellular
;
Immunologic Deficiency Syndromes/etiology/*immunology/*therapy
;
Severe Combined Immunodeficiency/immunology/therapy
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
