Publication Date:
1999-06-18
Description:
Neurotrophins have been implicated in activity-dependent synaptic plasticity, but the underlying intracellular mechanisms remain largely unknown. Synaptic potentiation induced by brain-derived neurotrophic factor (BDNF), but not neurotrophin 3, was prevented by blockers of adenosine 3',5'-monophosphate (cAMP) signaling. Activators of cAMP signaling alone were ineffective in modifying synaptic efficacy but greatly enhanced the potentiation effect of BDNF. Blocking cAMP signaling abolished the facilitation of BDNF-induced potentiation by presynaptic activity. Thus synaptic actions of BDNF are gated by cAMP. Activity and other coincident signals that modulate cAMP concentrations may specify the action of secreted neurotrophins on developing nerve terminals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boulanger, L -- Poo, M M -- NS 37831/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1999 Jun 18;284(5422):1982-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California at San Diego, La Jolla, CA 92093-0357, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10373115" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain-Derived Neurotrophic Factor/*pharmacology
;
*Carbazoles
;
Cells, Cultured
;
Cyclic AMP/analogs & derivatives/pharmacology/*physiology
;
Cycloleucine/analogs & derivatives/pharmacology
;
*Excitatory Postsynaptic Potentials/drug effects
;
Indoles/pharmacology
;
Nerve Growth Factors/pharmacology
;
Neuronal Plasticity
;
Neurons/cytology/physiology
;
Neurotrophin 3
;
Okadaic Acid/pharmacology
;
Patch-Clamp Techniques
;
Pyrroles/pharmacology
;
Signal Transduction
;
Synapses/drug effects/*physiology
;
*Synaptic Transmission/drug effects
;
Thionucleotides/pharmacology
;
Xenopus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
