Publication Date:
1999-03-12
Description:
Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hamada, F -- Tomoyasu, Y -- Takatsu, Y -- Nakamura, M -- Nagai, S -- Suzuki, A -- Fujita, F -- Shibuya, H -- Toyoshima, K -- Ueno, N -- Akiyama, T -- New York, N.Y. -- Science. 1999 Mar 12;283(5408):1739-42.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Oncogene Research, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita 565-0871, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10073940" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptor Proteins, Signal Transducing
;
Adenomatous Polyposis Coli Protein
;
Animals
;
Armadillo Domain Proteins
;
Axin Protein
;
Body Patterning
;
Carrier Proteins/chemistry/genetics/*metabolism
;
Chromosome Mapping
;
Cytoplasm/metabolism
;
Cytoskeletal Proteins/metabolism
;
Down-Regulation
;
Drosophila/*embryology/genetics/metabolism
;
*Drosophila Proteins
;
Embryo, Nonmammalian/metabolism
;
Extremities/embryology
;
Gene Expression Regulation, Developmental
;
Genes, Insect
;
Homeodomain Proteins/genetics/metabolism
;
In Situ Hybridization
;
Insect Proteins/genetics/metabolism
;
Molecular Sequence Data
;
Mutation
;
Phenotype
;
Proteins/chemistry/genetics/*metabolism
;
Proto-Oncogene Proteins/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
*Repressor Proteins
;
*Signal Transduction
;
*Trans-Activators
;
*Transcription Factors
;
Wings, Animal/embryology/metabolism
;
Wnt1 Protein
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
