Publication Date:
2016-04-30
Description:
Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These early-life events can have long-standing consequences: facilitating tolerance to environmental exposures or contributing to the development of disease in later life, including inflammatory bowel disease, allergy, and asthma. Recent studies have begun to define a critical period during early development in which disruption of optimal host-commensal interactions can lead to persistent and in some cases irreversible defects in the development and training of specific immune subsets. Here, we discuss the role of early-life education of the immune system during this "window of opportunity," when microbial colonization has a potentially critical impact on human health and disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gensollen, Thomas -- Iyer, Shankar S -- Kasper, Dennis L -- Blumberg, Richard S -- DK0034854/DK/NIDDK NIH HHS/ -- DK44319/DK/NIDDK NIH HHS/ -- R21 AI090102/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2016 Apr 29;352(6285):539-44. doi: 10.1126/science.aad9378.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ; Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA. ; Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. rblumberg@partners.org.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27126036" target="_blank"〉PubMed〈/a〉
Keywords:
Age Factors
;
Asthma/immunology/microbiology
;
Humans
;
Hypersensitivity/immunology/microbiology
;
Immune System/*immunology
;
Immune Tolerance
;
Infant, Newborn
;
Inflammatory Bowel Diseases/immunology/microbiology
;
Intestinal Mucosa/*immunology/*microbiology
;
Microbiota/*immunology
;
Natural Killer T-Cells/immunology
;
Symbiosis
;
T-Lymphocyte Subsets/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
