Publication Date:
2015-11-07
Description:
Corticomotoneuronal (CM) cells in the primary motor cortex (M1) have monosynaptic connections with motoneurons. They are one of the few sources of descending commands that directly influence motor output. We examined the contribution of CM cells to the generation of activity in their target muscles. The preferred direction of many CM cells differed from that of their target muscles. Some CM cells were selectively active when a muscle was used as an agonist. Others were selectively active when the same muscle was used as a synergist, fixator, or antagonist. These observations suggest that the different functional uses of a muscle are generated by separate populations of CM cells. We propose that muscle function is one of the dimensions represented in the output of M1.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Griffin, Darcy M -- Hoffman, Donna S -- Strick, Peter L -- FNS070366A/PHS HHS/ -- P30NS076405/NS/NINDS NIH HHS/ -- R01NS24328/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2015 Nov 6;350(6261):667-70. doi: 10.1126/science.aaa8035.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of Pittsburgh Brain Institute, Center for the Neural Basis of Cognition and Systems Neuroscience Institute, Pittsburgh, PA, USA. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. ; University of Pittsburgh Brain Institute, Center for the Neural Basis of Cognition and Systems Neuroscience Institute, Pittsburgh, PA, USA. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Research Service, Department of Veterans Affairs Medical Center, Pittsburgh, PA, USA. ; University of Pittsburgh Brain Institute, Center for the Neural Basis of Cognition and Systems Neuroscience Institute, Pittsburgh, PA, USA. Department of Neurobiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. Research Service, Department of Veterans Affairs Medical Center, Pittsburgh, PA, USA. strickp@pitt.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26542568" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Hand/innervation/*physiology
;
Haplorhini
;
Motor Cortex/cytology/*physiology
;
Motor Neurons/cytology/*physiology
;
Movement/physiology
;
Muscle, Skeletal/innervation/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
