Publication Date:
2015-06-13
Description:
Sex determination is an essential step in the commitment of a germ cell to a sperm or egg. However, the intrinsic factors that determine the sexual fate of vertebrate germ cells are unknown. Here, we show that foxl3, which is expressed in germ cells but not somatic cells in the gonad, is involved in sperm-egg fate decision in medaka fish. Adult XX medaka with disrupted foxl3 developed functional sperm in the expanded germinal epithelium of a histologically functional ovary. In chimeric medaka, mutant germ cells initiated spermatogenesis in female wild-type gonad. These results indicate that a germ cell-intrinsic cue for the sperm-egg fate decision is present in medaka and that spermatogenesis can proceed in a female gonadal environment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nishimura, Toshiya -- Sato, Tetsuya -- Yamamoto, Yasuhiro -- Watakabe, Ikuko -- Ohkawa, Yasuyuki -- Suyama, Mikita -- Kobayashi, Satoru -- Tanaka, Minoru -- New York, N.Y. -- Science. 2015 Jul 17;349(6245):328-31. doi: 10.1126/science.aaa2657. Epub 2015 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan. Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan. ; Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), Fukuoka 812-8582, Japan. ; Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan. ; Department of Advanced Medical Initiatives, JST-CREST, Faculty of Medicine, Kyushu University, Fukuoka 812-8582, Japan. ; Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan. Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, Okazaki 444-8787, Japan. ; Laboratory of Molecular Genetics for Reproduction, National Institute for Basic Biology, Okazaki 444-8787, Japan. Graduate University for Advanced Studies (SOKENDAI), Okazaki 444-8585, Japan. mtanaka@nibb.ac.jp.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26067255" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Female
;
Forkhead Transcription Factors/genetics/*physiology
;
Male
;
Oocytes/cytology/*physiology
;
Oryzias/genetics/*growth & development
;
Sex Determination Processes/*genetics
;
Spermatogenesis/genetics
;
Spermatozoa/cytology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
