Publication Date:
2014-12-06
Description:
Tobacco smoking is a risk factor for numerous disorders, including cancers affecting organs outside the respiratory tract. Epidemiological data suggest that smoking is a greater risk factor for these cancers in males compared with females. This observation, together with the fact that males have a higher incidence of and mortality from most non-sex-specific cancers, remains unexplained. Loss of chromosome Y (LOY) in blood cells is associated with increased risk of nonhematological tumors. We demonstrate here that smoking is associated with LOY in blood cells in three independent cohorts [TwinGene: odds ratio (OR) = 4.3, 95% confidence interval (CI) = 2.8 to 6.7; Uppsala Longitudinal Study of Adult Men: OR = 2.4, 95% CI = 1.6 to 3.6; and Prospective Investigation of the Vasculature in Uppsala Seniors: OR = 3.5, 95% CI = 1.4 to 8.4] encompassing a total of 6014 men. The data also suggest that smoking has a transient and dose-dependent mutagenic effect on LOY status. The finding that smoking induces LOY thus links a preventable risk factor with the most common acquired human mutation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356728/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356728/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dumanski, Jan P -- Rasi, Chiara -- Lonn, Mikael -- Davies, Hanna -- Ingelsson, Martin -- Giedraitis, Vilmantas -- Lannfelt, Lars -- Magnusson, Patrik K E -- Lindgren, Cecilia M -- Morris, Andrew P -- Cesarini, David -- Johannesson, Magnus -- Tiensuu Janson, Eva -- Lind, Lars -- Pedersen, Nancy L -- Ingelsson, Erik -- Forsberg, Lars A -- 086596/Z/08/Z/Wellcome Trust/United Kingdom -- 098017/Wellcome Trust/United Kingdom -- DK U01-066134/DK/NIDDK NIH HHS/ -- WT064890/Wellcome Trust/United Kingdom -- WT090532/Wellcome Trust/United Kingdom -- WT098017/Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2015 Jan 2;347(6217):81-3. doi: 10.1126/science.1262092. Epub 2014 Dec 4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Science for Life Laboratory, Uppsala University, Uppsala, Sweden. jan.dumanski@igp.uu.se lars.forsberg@igp.uu.se. ; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. Science for Life Laboratory, Uppsala University, Uppsala, Sweden. ; Sodertorn University, School of Life Sciences, Biology, Huddinge, Sweden. ; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden. ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts, USA. ; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. Department of Biostatistics, University of Liverpool, Liverpool, UK. ; Center for Experimental Social Science, New York University, New York, NY 10012, USA. ; Department of Economics, Stockholm School of Economics, Stockholm, Sweden. ; Department of Medical Sciences, Uppsala University, Uppsala, Sweden. ; Science for Life Laboratory, Uppsala University, Uppsala, Sweden. Department of Medical Sciences, Uppsala University, Uppsala, Sweden.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25477213" target="_blank"〉PubMed〈/a〉
Keywords:
Aged
;
Aged, 80 and over
;
Blood Cells/metabolism
;
Chromosomes, Human, Y/*genetics
;
Cohort Studies
;
Female
;
Humans
;
Incidence
;
Lung Neoplasms/*epidemiology/*genetics
;
Male
;
Middle Aged
;
Mutagenesis
;
Risk Factors
;
Sex Factors
;
*Smoking
;
Sweden
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
