Publication Date:
2014-06-14
Description:
Neural crest cells migrate extensively and give rise to most of the peripheral nervous system, including sympathetic, parasympathetic, enteric, and dorsal root ganglia. We studied how parasympathetic ganglia form close to visceral organs and what their precursors are. We find that many cranial nerve-associated crest cells coexpress the pan-autonomic determinant Paired-like homeodomain 2b (Phox2b) together with markers of Schwann cell precursors. Some give rise to Schwann cells after down-regulation of PHOX2b. Others form parasympathetic ganglia after being guided to the site of ganglion formation by the nerves that carry preganglionic fibers, a parsimonious way of wiring the pathway. Thus, cranial Schwann cell precursors are the source of parasympathetic neurons during normal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Espinosa-Medina, I -- Outin, E -- Picard, C A -- Chettouh, Z -- Dymecki, S -- Consalez, G G -- Coppola, E -- Brunet, J-F -- P01 HD036379/HD/NICHD NIH HHS/ -- R01 DK067826/DK/NIDDK NIH HHS/ -- R21 DA023643/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2014 Jul 4;345(6192):87-90. doi: 10.1126/science.1253286. Epub 2014 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie de l'Ecole Normale Superieure, Inserm U1024, and CNRS UMR 8197, 75005 Paris, France. ; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. ; Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy. ; Institut de Biologie de l'Ecole Normale Superieure, Inserm U1024, and CNRS UMR 8197, 75005 Paris, France. jfbrunet@biologie.ens.fr.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24925912" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basic Helix-Loop-Helix Transcription Factors/genetics/metabolism
;
Cranial Nerves/cytology/metabolism
;
Down-Regulation
;
Ganglia, Parasympathetic/cytology/*embryology
;
Homeodomain Proteins/genetics/*metabolism
;
Mice
;
Mice, Knockout
;
Nerve Tissue Proteins/genetics/metabolism
;
Neural Crest/cytology/metabolism
;
Neural Stem Cells/*cytology
;
Neurogenesis/genetics/*physiology
;
Neurons/*cytology
;
Schwann Cells/*cytology
;
Transcription Factors/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
