Publication Date:
2014-06-14
Description:
Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it is taken from its niche and challenged to de novo tissue morphogenesis after transplantation. In this Review, we discuss how different populations of naturally lineage-restricted stem cells and committed progenitors can display remarkable plasticity and reversibility and reacquire long-term self-renewing capacities and multilineage differentiation potential during physiological and regenerative conditions. We also discuss the implications of cellular plasticity for regenerative medicine and for cancer.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523269/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523269/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Blanpain, Cedric -- Fuchs, Elaine -- R01 AR031737/AR/NIAMS NIH HHS/ -- R01 AR050452/AR/NIAMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2014 Jun 13;344(6189):1242281. doi: 10.1126/science.1242281. Epub 2014 Jun 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Recherche Interdisciplinaire en Biologie Humaine et Moleculaire (IRIBHM), Universite Libre de Bruxelles, Brussels B-1070, Belgium. Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Universite Libre de Bruxelles (ULB), Brussels B-1070, Belgium. fuchslb@rockefeller.edu cedric.blanpain@ulb.ac.be. ; Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. fuchslb@rockefeller.edu cedric.blanpain@ulb.ac.be.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24926024" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carcinogenesis/pathology
;
Cell Lineage
;
Cell Tracking
;
Epithelial Cells/cytology/pathology/*physiology
;
Epithelium/physiology
;
Humans
;
*Regeneration
;
Regenerative Medicine/trends
;
Stem Cells/cytology/pathology/*physiology
;
Wound Healing
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
