Publikationsdatum:
2013-08-03
Beschreibung:
The Y chromosome and the mitochondrial genome have been used to estimate when the common patrilineal and matrilineal ancestors of humans lived. We sequenced the genomes of 69 males from nine populations, including two in which we find basal branches of the Y-chromosome tree. We identify ancient phylogenetic structure within African haplogroups and resolve a long-standing ambiguity deep within the tree. Applying equivalent methodologies to the Y chromosome and the mitochondrial genome, we estimate the time to the most recent common ancestor (T(MRCA)) of the Y chromosome to be 120 to 156 thousand years and the mitochondrial genome T(MRCA) to be 99 to 148 thousand years. Our findings suggest that, contrary to previous claims, male lineages do not coalesce significantly more recently than female lineages.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032117/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032117/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Poznik, G David -- Henn, Brenna M -- Yee, Muh-Ching -- Sliwerska, Elzbieta -- Euskirchen, Ghia M -- Lin, Alice A -- Snyder, Michael -- Quintana-Murci, Lluis -- Kidd, Jeffrey M -- Underhill, Peter A -- Bustamante, Carlos D -- 3R01HG003229/HG/NHGRI NIH HHS/ -- DP5 OD009154/OD/NIH HHS/ -- DP5OD009154/OD/NIH HHS/ -- LM-07033/LM/NLM NIH HHS/ -- R01 HG003229/HG/NHGRI NIH HHS/ -- T15 LM007033/LM/NLM NIH HHS/ -- New York, N.Y. -- Science. 2013 Aug 2;341(6145):562-5. doi: 10.1126/science.1237619.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23908239" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
African Continental Ancestry Group/genetics
;
Chromosomes, Human, Y/*classification/*genetics
;
Evolution, Molecular
;
Female
;
*Genetic Variation
;
Genome, Mitochondrial/genetics
;
Haploidy
;
Humans
;
Male
;
Mutation
;
Phylogeny
;
Sequence Analysis, DNA
;
Time Factors
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
