Publication Date:
2013-03-30
Description:
The past decade has brought together substantial advances in human genome analysis and a maturation of understanding of tumor biology. Although there is much progress still to be made, there are now several prominent examples in which tumor-associated somatic mutations have been used to identify cellular signaling pathways in tumors. This in turn has led to the development of targeted therapies, with somatic mutations serving as genomic predictors of tumor response and providing new leads for drug development. There is also a realization that germline DNA variants can help optimize cancer drug dosing and predict the susceptibility of patients to the adverse side effects of these drugs-knowledge that ultimately can be used to improve the benefit:risk ratio of cancer treatment for individual patients.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900028/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900028/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McLeod, Howard L -- P01 CA142538/CA/NCI NIH HHS/ -- P01CA142538/CA/NCI NIH HHS/ -- R01 CA161608/CA/NCI NIH HHS/ -- R01HL110380/HL/NHLBI NIH HHS/ -- UL1 RR025747/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 2013 Mar 29;339(6127):1563-6. doi: 10.1126/science.1234139.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Pharmacogenomics and Individualized Therapy, University of North Carolina, Chapel Hill, NC 27599, USA. hmcleod@unc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23539596" target="_blank"〉PubMed〈/a〉
Keywords:
Antineoplastic Agents/administration & dosage/adverse effects/*therapeutic use
;
Biomarkers, Pharmacological
;
Biomarkers, Tumor/*genetics
;
Drug Design
;
Female
;
Genetic Markers
;
Genome, Human
;
Germ-Line Mutation
;
Humans
;
*Molecular Targeted Therapy
;
Neoplasms/*drug therapy/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
