Publication Date:
2012-06-08
Description:
The composition and activity of the gut microbiota codevelop with the host from birth and is subject to a complex interplay that depends on the host genome, nutrition, and life-style. The gut microbiota is involved in the regulation of multiple host metabolic pathways, giving rise to interactive host-microbiota metabolic, signaling, and immune-inflammatory axes that physiologically connect the gut, liver, muscle, and brain. A deeper understanding of these axes is a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nicholson, Jeremy K -- Holmes, Elaine -- Kinross, James -- Burcelin, Remy -- Gibson, Glenn -- Jia, Wei -- Pettersson, Sven -- R01AA020212/AA/NIAAA NIH HHS/ -- Biotechnology and Biological Sciences Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1262-7. doi: 10.1126/science.1223813. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK. j.nicholson@imperial.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674330" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Bacteria/*metabolism
;
Diet
;
Gastrointestinal Tract/*metabolism/*microbiology
;
Health
;
Humans
;
Immune System/physiology
;
Inflammation
;
Liver/metabolism
;
Metabolic Diseases/metabolism/*microbiology
;
*Metabolic Networks and Pathways
;
*Metagenome
;
Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
