Publication Date:
2012-06-08
Description:
The large numbers of microorganisms that inhabit mammalian body surfaces have a highly coevolved relationship with the immune system. Although many of these microbes carry out functions that are critical for host physiology, they nevertheless pose the threat of breach with ensuing pathologies. The mammalian immune system plays an essential role in maintaining homeostasis with resident microbial communities, thus ensuring that the mutualistic nature of the host-microbial relationship is maintained. At the same time, resident bacteria profoundly shape mammalian immunity. Here, we review advances in our understanding of the interactions between resident microbes and the immune system and the implications of these findings for human health.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420145/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420145/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hooper, Lora V -- Littman, Dan R -- Macpherson, Andrew J -- AI080885/AI/NIAID NIH HHS/ -- DK070855/DK/NIDDK NIH HHS/ -- R01 AI080885/AI/NIAID NIH HHS/ -- R01 DK070855/DK/NIDDK NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 Jun 8;336(6086):1268-73. doi: 10.1126/science.1223490. Epub 2012 Jun 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Howard Hughes Medical Institute and Department of Immunology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA. lora.hooper@utsouthwestern.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22674334" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Autoimmune Diseases/immunology/microbiology
;
Bacteria/immunology
;
*Bacterial Physiological Phenomena
;
Germ-Free Life
;
High-Throughput Nucleotide Sequencing
;
Humans
;
Immune System/physiology
;
*Immunity
;
Immunity, Innate
;
Immunity, Mucosal
;
Immunocompromised Host
;
Inflammation
;
Intestines/*immunology/*microbiology
;
Lymphoid Tissue/immunology
;
Metabolic Syndrome X/immunology/microbiology
;
Metagenome/immunology/*physiology
;
Symbiosis
;
T-Lymphocyte Subsets/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
