Publication Date:
2012-08-11
Description:
Many neurological and psychiatric diseases are associated with clinically detectable, altered brain dynamics. The aberrant brain activity, in principle, can be restored through electrical stimulation. In epilepsies, abnormal patterns emerge intermittently, and therefore, a closed-loop feedback brain control that leaves other aspects of brain functions unaffected is desirable. Here, we demonstrate that seizure-triggered, feedback transcranial electrical stimulation (TES) can dramatically reduce spike-and-wave episodes in a rodent model of generalized epilepsy. Closed-loop TES can be an effective clinical tool to reduce pathological brain patterns in drug-resistant patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berenyi, Antal -- Belluscio, Mariano -- Mao, Dun -- Buzsaki, Gyorgy -- MH54671/MH/NIMH NIH HHS/ -- NS074015/NS/NINDS NIH HHS/ -- NS34994/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Aug 10;337(6095):735-7. doi: 10.1126/science.1223154.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, NJ 07102, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22879515" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Brain Waves
;
Cerebral Cortex/physiopathology
;
*Deep Brain Stimulation
;
Electric Stimulation
;
Electrodes, Implanted
;
Epilepsy, Absence/physiopathology/*therapy
;
Feedback, Physiological
;
Male
;
Rats
;
Rats, Long-Evans
;
Thalamus/physiopathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
