Publication Date:
2012-09-18
Description:
Early social isolation results in adult behavioral and cognitive dysfunction that correlates with white matter alterations. However, how social deprivation influences myelination and the significance of these myelin defects in the adult remained undefined. We show that mice isolated for 2 weeks immediately after weaning have alterations in prefrontal cortex function and myelination that do not recover with reintroduction into a social environment. These alterations, which occur only during this critical period, are phenocopied by loss of oligodendrocyte ErbB3 receptors, and social isolation leads to reduced expression of the ErbB3 ligand neuregulin-1. These findings indicate that social experience regulates prefrontal cortex myelination through neuregulin-1/ErbB3 signaling and that this is essential for normal cognitive function, thus providing a cellular and molecular context to understand the consequences of social isolation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165613/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165613/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Makinodan, Manabu -- Rosen, Kenneth M -- Ito, Susumu -- Corfas, Gabriel -- P30 HD018655/HD/NICHD NIH HHS/ -- P30-HD 18655/HD/NICHD NIH HHS/ -- R01 NS035884/NS/NINDS NIH HHS/ -- R01 NS35884/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2012 Sep 14;337(6100):1357-60. doi: 10.1126/science.1220845.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉F. M. Kirby Neurobiology Center, Children's Hospital, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22984073" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Behavior, Animal
;
Female
;
Green Fluorescent Proteins/genetics/metabolism
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Myelin Sheath/*metabolism
;
Neuregulin-1/genetics/metabolism
;
Oligodendroglia/cytology/*metabolism
;
Prefrontal Cortex/cytology/*metabolism
;
Receptor, ErbB-3/genetics/metabolism
;
Signal Transduction
;
*Social Isolation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
