Publication Date:
2011-04-09
Description:
The unfolded protein response (UPR), which is activated when unfolded or misfolded proteins accumulate in the endoplasmic reticulum, has been implicated in the normal physiology of immune defense and in several human diseases, including diabetes, cancer, neurodegenerative disease, and inflammatory disease. In this study, we found that the nervous system controlled the activity of a noncanonical UPR pathway required for innate immunity in Caenorhabditis elegans. OCTR-1, a putative octopamine G protein-coupled catecholamine receptor (GPCR, G protein-coupled receptor), functioned in sensory neurons designated ASH and ASI to actively suppress innate immune responses by down-regulating the expression of noncanonical UPR genes pqn/abu in nonneuronal tissues. Our findings suggest a molecular mechanism by which the nervous system may sense inflammatory responses and respond by controlling stress-response pathways at the organismal level.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125668/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125668/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sun, Jingru -- Singh, Varsha -- Kajino-Sakamoto, Rie -- Aballay, Alejandro -- GM070977/GM/NIGMS NIH HHS/ -- R01 GM070977/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 May 6;332(6030):729-32. doi: 10.1126/science.1203411. Epub 2011 Apr 7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27705, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21474712" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bacterial Load
;
Caenorhabditis elegans/*genetics/*immunology/microbiology
;
Caenorhabditis elegans Proteins/genetics/metabolism/*physiology
;
Down-Regulation
;
Endoplasmic Reticulum/metabolism
;
*Genes, Helminth
;
*Immunity, Innate
;
Intestines/metabolism
;
Membrane Proteins/genetics/metabolism
;
Mitogen-Activated Protein Kinases/genetics/metabolism
;
Mutation
;
Pharynx/metabolism
;
Pseudomonas aeruginosa/*immunology/pathogenicity
;
Receptors, G-Protein-Coupled/genetics/*physiology
;
Sensory Receptor Cells/*physiology
;
Signal Transduction
;
Stress, Physiological
;
Transcription, Genetic
;
Unfolded Protein Response/*genetics
;
Up-Regulation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
