Publication Date:
2011-06-28
Description:
Sleep is believed to play an important role in memory consolidation. We induced sleep on demand by expressing the temperature-gated nonspecific cation channel Transient receptor potential cation channel (UAS-TrpA1) in neurons, including those with projections to the dorsal fan-shaped body (FB). When the temperature was raised to 31 degrees C, flies entered a quiescent state that meets the criteria for identifying sleep. When sleep was induced for 4 hours after a massed-training protocol for courtship conditioning that is not capable of inducing long-term memory (LTM) by itself, flies develop an LTM. Activating the dorsal FB in the absence of sleep did not result in the formation of LTM after massed training.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064462/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064462/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donlea, Jeffrey M -- Thimgan, Matthew S -- Suzuki, Yasuko -- Gottschalk, Laura -- Shaw, Paul J -- 5F31NS063514-02/NS/NINDS NIH HHS/ -- NS057105/NS/NINDS NIH HHS/ -- R01 NS051305/NS/NINDS NIH HHS/ -- R01-NS051305-01A1/NS/NINDS NIH HHS/ -- T32GM008151/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jun 24;332(6037):1571-6. doi: 10.1126/science.1202249.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, Washington University in St. Louis, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21700877" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Conditioning (Psychology)
;
Drosophila/genetics/*physiology
;
Drosophila Proteins/genetics/metabolism
;
Female
;
Memory, Long-Term/*physiology
;
Models, Animal
;
Motor Activity
;
Neurons/*physiology
;
Presynaptic Terminals/physiology
;
Sleep/*physiology
;
Social Isolation
;
Temperature
;
Transcription Factors/genetics/metabolism
;
Transient Receptor Potential Channels/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
