Publication Date:
2010-12-04
Description:
Autophagy is a process of self-cannibalization. Cells capture their own cytoplasm and organelles and consume them in lysosomes. The resulting breakdown products are inputs to cellular metabolism, through which they are used to generate energy and to build new proteins and membranes. Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010857/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010857/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rabinowitz, Joshua D -- White, Eileen -- R01 CA130893/CA/NCI NIH HHS/ -- R01 CA130893-03/CA/NCI NIH HHS/ -- R37 CA053370/CA/NCI NIH HHS/ -- R37 CA053370-19/CA/NCI NIH HHS/ -- RC1 CA147961/CA/NCI NIH HHS/ -- RC1 CA147961-02/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2010 Dec 3;330(6009):1344-8. doi: 10.1126/science.1193497.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, 241 Carl Icahn Laboratory, Washington Road, Princeton University, Princeton, NJ 08544, USA. joshr@genomics.princeton.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21127245" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Autophagy
;
Cell Survival
;
Disease
;
Energy Metabolism
;
Homeostasis
;
Humans
;
*Metabolism
;
Neoplasms/metabolism/pathology
;
Phagosomes/metabolism
;
Proteins/metabolism
;
Signal Transduction
;
Starvation
;
TOR Serine-Threonine Kinases/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
