Publication Date:
2010-07-22
Description:
Annelids and arthropods share a similar segmented organization of the body whose evolutionary origin remains unclear. The Hedgehog signaling pathway, prominent in arthropod embryonic segment patterning, has not been shown to have a similar function outside arthropods. We show that the ligand Hedgehog, the receptor Patched, and the transcription factor Gli are all expressed in striped patterns before the morphological appearance of segments in the annelid Platynereis dumerilii. Treatments with small molecules antagonistic to Hedgehog signaling disrupt segment formation. Platynereis Hedgehog is not necessary to establish early segment patterns but is required to maintain them. The molecular similarity of segment patterning functions of the Hedgehog pathway in an annelid and in arthropods supports a common origin of segmentation in protostomes.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182550/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182550/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dray, Nicolas -- Tessmar-Raible, Kristin -- Le Gouar, Martine -- Vibert, Laura -- Christodoulou, Foteini -- Schipany, Katharina -- Guillou, Aurelien -- Zantke, Juliane -- Snyman, Heidi -- Behague, Julien -- Vervoort, Michel -- Arendt, Detlev -- Balavoine, Guillaume -- Y 413/Austrian Science Fund FWF/Austria -- New York, N.Y. -- Science. 2010 Jul 16;329(5989):339-42. doi: 10.1126/science.1188913.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre de Genetique Moleculaire du CNRS, FRE 3144, Avenue de la Terrasse, 91189 Gif-sur-Yvette, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20647470" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Arthropods/embryology/genetics/growth & development/metabolism
;
Biological Evolution
;
Body Patterning/drug effects
;
Gene Expression Profiling
;
Gene Expression Regulation, Developmental
;
Hedgehog Proteins/chemistry/genetics/*metabolism
;
Larva/genetics/growth & development/metabolism
;
Metamorphosis, Biological
;
Molecular Sequence Data
;
Phylogeny
;
Piperazines/pharmacology
;
Polychaeta/anatomy & histology/genetics/*growth & development/*metabolism
;
Pyrazoles/pharmacology
;
Receptors, Cell Surface/chemistry/genetics/*metabolism
;
*Signal Transduction/drug effects
;
Transcription Factors/chemistry/genetics/*metabolism
;
Veratrum Alkaloids/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
