Publication Date:
2010-06-05
Description:
Staphylococcus aureus is a major human pathogen that is resistant to numerous antibiotics in clinical use. We found two nonribosomal peptide secondary metabolites--the aureusimines, made by S. aureus--that are not antibiotics, but function as regulators of virulence factor expression and are necessary for productive infections. In vivo mouse models of bacteremia showed that strains of S. aureus unable to produce aureusimines were attenuated and/or cleared from major organs, including the spleen, liver, and heart. Targeting aureusimine synthesis may offer novel leads for anti-infective drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wyatt, Morgan A -- Wang, Wenliang -- Roux, Christelle M -- Beasley, Federico C -- Heinrichs, David E -- Dunman, Paul M -- Magarvey, Nathan A -- MOP-38002/Canadian Institutes of Health Research/Canada -- RA107380/RA/ARRA NIH HHS/ -- New York, N.Y. -- Science. 2010 Jul 16;329(5989):294-6. doi: 10.1126/science.1188888. Epub 2010 Jun 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biomedical Sciences, M. G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20522739" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Bacteremia/microbiology
;
Dipeptides/chemistry/isolation & purification
;
Heart/microbiology
;
Hemolysis
;
Liver/microbiology
;
Mice
;
Mice, Inbred BALB C
;
Molecular Sequence Data
;
Oligonucleotide Array Sequence Analysis
;
Peptide Biosynthesis, Nucleic Acid-Independent
;
Peptide Synthases/chemistry/genetics/metabolism
;
Pyrazines/chemistry/*metabolism
;
Spleen/microbiology
;
Staphylococcal Infections/*microbiology
;
Staphylococcus aureus/genetics/isolation &
;
purification/*metabolism/*pathogenicity
;
Virulence Factors/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
