Publication Date:
2010-06-19
Description:
Orienting in large-scale space depends on the interaction of environmental experience and preconfigured, possibly innate, constructs. Place, head-direction, and grid cells in the hippocampal formation provide allocentric representations of space. Here we show how these cognitive representations emerge and develop as rat pups first begin to explore their environment. Directional, locational, and rhythmic organization of firing are present during initial exploration, including adultlike directional firing. The stability and precision of place cell firing continue to develop throughout juvenility. Stable grid cell firing appears later but matures rapidly to adult levels. Our results demonstrate the presence of three neuronal representations of space before extensive experience and show how they develop with age.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543985/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3543985/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wills, Tom J -- Cacucci, Francesca -- Burgess, Neil -- O'Keefe, John -- 082507/Wellcome Trust/United Kingdom -- G0501672/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2010 Jun 18;328(5985):1573-6. doi: 10.1126/science.1188224.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cell and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. t.wills@ucl.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20558720" target="_blank"〉PubMed〈/a〉
Keywords:
Action Potentials
;
Aging
;
Animals
;
Animals, Suckling
;
Brain Mapping
;
CA1 Region, Hippocampal/cytology/*physiology
;
*Cognition
;
Electrodes, Implanted
;
Entorhinal Cortex/cytology/*physiology
;
Exploratory Behavior
;
Male
;
Neurons/*physiology
;
Orientation
;
Pyramidal Cells/*physiology
;
Rats
;
*Space Perception
;
*Spatial Behavior
;
Theta Rhythm
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
