Publication Date:
2010-01-16
Description:
Virus infection in mammals elicits a variety of defense responses that are initiated by signals from virus-sensing receptors expressed by the host. These receptors include the ubiquitously expressed RIG-I-like receptor (RLR) family of RNA helicases. RLRs are cytoplasmic proteins that act in cell-intrinsic antiviral defense by recognizing RNAs indicative of virus presence. Here, we highlight recent progress in understanding how RLRs discriminate between the RNA content of healthy versus virus-infected cells, functioning as accurate sensors of virus invasion.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rehwinkel, Jan -- Reis e Sousa, Caetano -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2010 Jan 15;327(5963):284-6. doi: 10.1126/science.1185068.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunobiology Laboratory, Cancer Research UK (CRUK) London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075242" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Pairing
;
DEAD-box RNA Helicases/chemistry/immunology/*metabolism
;
Genome, Viral
;
Humans
;
*Immunity, Innate
;
Interferons/biosynthesis
;
Nucleic Acid Conformation
;
Protein Structure, Tertiary
;
RNA Virus Infections/*immunology
;
RNA Viruses/genetics/*immunology
;
RNA, Double-Stranded/immunology/metabolism
;
RNA, Viral/chemistry/*immunology/*metabolism
;
Receptors, Pattern Recognition/chemistry/immunology/*metabolism
;
Signal Transduction
;
Viral Proteins/immunology/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
