Publication Date:
2010-01-16
Description:
Twenty years after the proposal that pattern recognition receptors detect invasion by microbial pathogens, the field of immunology has witnessed several discoveries that have elucidated receptors and signaling pathways of microbial recognition systems and how they control the generation of T and B lymphocyte-mediated immune responses. However, there are still many fundamental questions that remain poorly understood, even though sometimes the answers are assumed to be known. Here, we discuss some of these questions, including the mechanisms by which pathogen-specific innate immune recognition activates antigen-specific adaptive immune responses and the roles of different types of innate immune recognition in host defense from infection and injury.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645875/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645875/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Iwasaki, Akiko -- Medzhitov, Ruslan -- R01 AI054359/AI/NIAID NIH HHS/ -- R01 AI055502/AI/NIAID NIH HHS/ -- R01 AI062428/AI/NIAID NIH HHS/ -- R01 AI064705/AI/NIAID NIH HHS/ -- R01 AI081884/AI/NIAID NIH HHS/ -- R01AI054359/AI/NIAID NIH HHS/ -- R01AI055502/AI/NIAID NIH HHS/ -- R01AI064705/AI/NIAID NIH HHS/ -- R01DK071754/DK/NIDDK NIH HHS/ -- R21AI083242/AI/NIAID NIH HHS/ -- R37AI046688/AI/NIAID NIH HHS/ -- U54 AI057160/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Jan 15;327(5963):291-5. doi: 10.1126/science.1183021.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunobiology, School of Medicine, Yale University, New Haven, CT 06520, USA. akiko.iwasaki@yale.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20075244" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptive Immunity
;
Animals
;
Antigen-Presenting Cells/immunology
;
Bacterial Infections/*immunology
;
Humans
;
*Immunity, Innate
;
Ligands
;
Receptors, Pattern Recognition/immunology/*metabolism
;
Signal Transduction
;
Toll-Like Receptors/immunology/metabolism
;
Virus Diseases/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
