Publication Date:
2010-01-30
Description:
Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and in a lower metabolic state) and active (in cell cycle and not able to retain DNA labels) stem cell subpopulations may coexist in several tissues, in separate yet adjoining locations. Here, we summarize these findings and propose that quiescent and active stem cell populations have separate but cooperative functional roles.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105182/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4105182/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Linheng -- Clevers, Hans -- U01 DK085507/DK/NIDDK NIH HHS/ -- U01DK085507/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 29;327(5965):542-5. doi: 10.1126/science.1180794.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Stowers Institute for Medical Research (SIMR), Kansas City, MO 64110, USA. lil@stowers.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20110496" target="_blank"〉PubMed〈/a〉
Keywords:
Adult Stem Cells/cytology/*physiology
;
Animals
;
*Cell Cycle
;
Cell Differentiation
;
Cell Lineage
;
Hair Follicle/cytology
;
Hematopoietic Stem Cells/cytology/physiology
;
Humans
;
Intestinal Mucosa/cytology
;
Mammals/*physiology
;
Models, Biological
;
Stem Cell Niche
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
