Publication Date:
2008-11-29
Description:
Plant growth and development are sustained by meristems. Meristem activity is controlled by auxin and cytokinin, two hormones whose interactions in determining a specific developmental output are still poorly understood. By means of a comprehensive genetic and molecular analysis in Arabidopsis, we show that a primary cytokinin-response transcription factor, ARR1, activates the gene SHY2/IAA3 (SHY2), a repressor of auxin signaling that negatively regulates the PIN auxin transport facilitator genes: thereby, cytokinin causes auxin redistribution, prompting cell differentiation. Conversely, auxin mediates degradation of the SHY2 protein, sustaining PIN activities and cell division. Thus, the cell differentiation and division balance necessary for controlling root meristem size and root growth is the result of the interaction between cytokinin and auxin through a simple regulatory circuit converging on the SHY2 gene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dello Ioio, Raffaele -- Nakamura, Kinu -- Moubayidin, Laila -- Perilli, Serena -- Taniguchi, Masatoshi -- Morita, Miyo T -- Aoyama, Takashi -- Costantino, Paolo -- Sabatini, Sabrina -- New York, N.Y. -- Science. 2008 Nov 28;322(5906):1380-4. doi: 10.1126/science.1164147.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Dipartimento di Genetica e Biologia Molecolare, Laboratorio di Genomica e Proteomica Funzionale dei Sistemi Modello (FGPL), Universita La Sapienza - Piazzale Aldo Moro 5, 00185 Rome, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19039136" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/*cytology/genetics/growth & development/metabolism
;
Arabidopsis Proteins/*genetics/*metabolism
;
Cell Differentiation
;
Cell Division
;
Cytokinins/genetics/*metabolism
;
DNA-Binding Proteins/genetics/*metabolism
;
Gene Expression Regulation, Plant
;
Genes, Plant
;
Indoleacetic Acids/*metabolism
;
Membrane Transport Proteins/genetics/metabolism
;
Meristem/*cytology/growth & development
;
Nuclear Proteins/*genetics/metabolism
;
Plant Roots/*cytology/growth & development
;
Promoter Regions, Genetic
;
Signal Transduction
;
Transcription Factors/genetics/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
