Publication Date:
2008-08-30
Description:
The acquisition of metastatic ability by tumor cells is considered a late event in the evolution of malignant tumors. We report that untransformed mouse mammary cells that have been engineered to express the inducible oncogenic transgenes MYC and Kras(D12), or polyoma middle T, and introduced into the systemic circulation of a mouse can bypass transformation at the primary site and develop into metastatic pulmonary lesions upon immediate or delayed oncogene induction. Therefore, previously untransformed mammary cells may establish residence in the lung once they have entered the bloodstream and may assume malignant growth upon oncogene activation. Mammary cells lacking oncogenic transgenes displayed a similar capacity for long-term residence in the lungs but did not form ectopic tumors.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694414/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694414/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Podsypanina, Katrina -- Du, Yi-Chieh Nancy -- Jechlinger, Martin -- Beverly, Levi J -- Hambardzumyan, Dolores -- Varmus, Harold -- K01 CA118731/CA/NCI NIH HHS/ -- K01 CA118731-03/CA/NCI NIH HHS/ -- P01 CA94060/CA/NCI NIH HHS/ -- P30-CA 08748/CA/NCI NIH HHS/ -- R24 CA83084/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2008 Sep 26;321(5897):1841-4. doi: 10.1126/science.1161621. Epub 2008 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Program in Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. podsypak@mskcc.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18755941" target="_blank"〉PubMed〈/a〉
Keywords:
Adenocarcinoma/pathology/secondary
;
Animals
;
Antigens, Polyomavirus Transforming/genetics
;
Cell Proliferation
;
Cell Survival
;
Cell Transformation, Neoplastic
;
Epithelial Cells/*cytology
;
Gene Expression Regulation, Neoplastic
;
Genes, myc
;
Genes, ras
;
Lung Neoplasms/pathology/*secondary
;
Mammary Glands, Animal/*cytology
;
Mammary Neoplasms, Experimental/pathology
;
Mice
;
Mice, Transgenic
;
*Neoplasm Metastasis
;
*Neoplasm Seeding
;
Neoplastic Cells, Circulating
;
*Oncogenes
;
Transgenes
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
