Publication Date:
2008-07-19
Description:
Cyclic di-guanosine monophosphate (di-GMP) is a circular RNA dinucleotide that functions as a second messenger in diverse species of bacteria to trigger wide-ranging physiological changes, including cell differentiation, conversion between motile and biofilm lifestyles, and virulence gene expression. However, the mechanisms by which cyclic di-GMP regulates gene expression have remained a mystery. We found that cyclic di-GMP in many bacterial species is sensed by a riboswitch class in messenger RNA that controls the expression of genes involved in numerous fundamental cellular processes. A variety of cyclic di-GMP regulons are revealed, including some riboswitches associated with virulence gene expression, pilus formation, and flagellum biosynthesis. In addition, sequences matching the consensus for cyclic di-GMP riboswitches are present in the genome of a bacteriophage.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sudarsan, N -- Lee, E R -- Weinberg, Z -- Moy, R H -- Kim, J N -- Link, K H -- Breaker, R R -- GM 068819/GM/NIGMS NIH HHS/ -- HV28186/HV/NHLBI NIH HHS/ -- R33 DK07027/DK/NIDDK NIH HHS/ -- RR19895-02/RR/NCRR NIH HHS/ -- T32GM007223/GM/NIGMS NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2008 Jul 18;321(5887):411-3. doi: 10.1126/science.1159519.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18635805" target="_blank"〉PubMed〈/a〉
Keywords:
Aptamers, Nucleotide/*metabolism
;
Bacillus cereus/genetics/metabolism
;
Bacteria/*genetics/metabolism
;
Bacteriophages/genetics
;
Base Sequence
;
Clostridium difficile/genetics/metabolism
;
Cyclic GMP/*analogs & derivatives/metabolism
;
*Gene Expression Regulation, Bacterial
;
Genes, Bacterial
;
Ligands
;
Molecular Sequence Data
;
Nucleic Acid Conformation
;
RNA, Bacterial/chemistry/*metabolism
;
RNA, Messenger/chemistry/*metabolism
;
Regulon
;
*Second Messenger Systems
;
Vibrio cholerae/genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
