Publication Date:
2007-10-06
Description:
The RRM-domain proteins FCA and FPA have previously been characterized as flowering-time regulators in Arabidopsis. We show that they are required for RNA-mediated chromatin silencing of a range of loci in the genome. At some target loci, FCA and FPA promote asymmetric DNA methylation, whereas at others they function in parallel to DNA methylation. Female gametophytic development and early embryonic development are particularly susceptible to malfunctions in FCA and FPA. We propose that FCA and FPA regulate chromatin silencing of single and low-copy genes and interact in a locus-dependent manner with the canonical small interfering RNA-directed DNA methylation pathway to regulate common targets.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baurle, Isabel -- Smith, Lisa -- Baulcombe, David C -- Dean, Caroline -- New York, N.Y. -- Science. 2007 Oct 5;318(5847):109-12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, John Innes Centre, Norwich NR4 7UH, UK. isabel.baurle@bbsrc.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17916737" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/*genetics/growth & development/metabolism
;
Arabidopsis Proteins/chemistry/genetics/*metabolism
;
Chromatin/*genetics
;
DNA Methylation
;
DNA Transposable Elements
;
DNA, Plant/metabolism
;
Flowers/growth & development
;
Mutation
;
Oxidoreductases/genetics
;
*RNA Interference
;
RNA, Plant/genetics
;
RNA, Small Interfering/genetics
;
RNA-Binding Proteins/chemistry/genetics/*metabolism
;
Retroelements
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
