Publication Date:
2006-12-13
Description:
GABA (gamma-aminobutyric acid), the major inhibitory transmitter in the brain, goes through a transitory phase of excitation during development. The excitatory phase promotes neuronal growth and integration into circuits. We show here that spontaneous nicotinic cholinergic activity is responsible for terminating GABAergic excitation and initiating inhibition. It does so by changing chloride transporter levels, shifting the driving force on GABA-induced currents. The timing of the transition is critical, because the two phases of GABAergic signaling provide contrasting developmental instructions. Synergistic with nicotinic excitation, GABAergic inhibition constrains neuronal morphology and innervation. The results reveal a multitiered activity-dependent strategy controlling neuronal development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Zhaoping -- Neff, Robert A -- Berg, Darwin K -- NS012601/NS/NINDS NIH HHS/ -- NS035469/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2006 Dec 8;314(5805):1610-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0357, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17158331" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cadmium/pharmacology
;
Calcium/metabolism
;
Chick Embryo
;
Chlorides/metabolism
;
Ganglia, Parasympathetic/cytology/embryology
;
Hippocampus/cytology/metabolism
;
Mice
;
Mice, Inbred C57BL
;
Mice, Knockout
;
Neurons/cytology/*physiology
;
Nicotine/metabolism/pharmacology
;
Nicotinic Antagonists/pharmacology
;
Patch-Clamp Techniques
;
Receptors, Nicotinic/*metabolism
;
Recombinant Fusion Proteins/metabolism
;
*Signal Transduction
;
Sodium-Potassium-Chloride Symporters/metabolism
;
Solute Carrier Family 12, Member 2
;
Symporters/genetics/metabolism
;
Synaptic Transmission
;
Transfection
;
alpha7 Nicotinic Acetylcholine Receptor
;
gamma-Aminobutyric Acid/*metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
