Publication Date:
2005-10-15
Description:
A proposed strategy to aid in controlling the growing burden of vector-borne disease is population replacement, in which a natural vector population is replaced by a population with a reduced capacity for disease transmission. An important component of such a strategy is the drive system, which serves to spread a desired genotype into the targeted field population. Endosymbiotic Wolbachia bacteria are potential transgene drivers, but infections do not naturally occur in some important mosquito vectors, notably Aedes aegypti. In this work, stable infections of wAlbB Wolbachia were established in A. aegypti and caused high rates of cytoplasmic incompatibility (that is, elimination of egg hatch). Laboratory cage tests demonstrated the ability of wAlbB to spread into an A. aegypti population after seeding of an uninfected population with infected females, reaching infection fixation within seven generations.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xi, Zhiyong -- Khoo, Cynthia C H -- Dobson, Stephen L -- AI-51533/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2005 Oct 14;310(5746):326-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of Kentucky, Lexington, KY 40546, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16224027" target="_blank"〉PubMed〈/a〉
Keywords:
Aedes/*microbiology
;
Animals
;
Crosses, Genetic
;
Cytoplasm
;
Female
;
Insect Vectors/microbiology
;
Male
;
Pest Control, Biological
;
Reproduction
;
Wolbachia/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
