Publication Date:
2005-11-15
Description:
Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by posttranslational processing. On the basis of the bioinformatic prediction that another peptide also derived from proghrelin exists, we isolated a hormone from rat stomach and named it obestatin-a contraction of obese, from the Latin "obedere," meaning to devour, and "statin," denoting suppression. Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain. Obestatin bound to the orphan G protein-coupled receptor GPR39. Thus, two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, Jian V -- Ren, Pei-Gen -- Avsian-Kretchmer, Orna -- Luo, Ching-Wei -- Rauch, Rami -- Klein, Cynthia -- Hsueh, Aaron J W -- New York, N.Y. -- Science. 2005 Nov 11;310(5750):996-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305-5317, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16284174" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
CHO Cells
;
Computational Biology
;
Conserved Sequence
;
Cricetinae
;
*Eating/drug effects
;
Fasting
;
Gastric Emptying/drug effects
;
Gastrointestinal Motility/drug effects
;
Ghrelin
;
Humans
;
In Vitro Techniques
;
Ligands
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Molecular Sequence Data
;
Peptide Hormones/blood/chemistry/*genetics/metabolism/pharmacology/*physiology
;
Protein Binding
;
Protein Precursors/*genetics
;
Radioimmunoassay
;
Rats
;
Rats, Sprague-Dawley
;
Receptors, G-Protein-Coupled/metabolism
;
Receptors, Ghrelin
;
Signal Transduction
;
Weight Gain/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
