Publication Date:
2005-11-29
Description:
Wingless secretion provides pivotal signals during development by activating transcription of target genes. At Drosophila synapses, Wingless is secreted from presynaptic terminals and is required for synaptic growth and differentiation. Wingless binds the seven-pass transmembrane DFrizzled2 receptor, but the ensuing events at synapses are not known. We show that DFrizzled2 is endocytosed from the postsynaptic membrane and transported to the nucleus. The C terminus of DFrizzled2 is cleaved and translocated into the nucleus; the N-terminal region remains just outside the nucleus. Translocation of DFrizzled2-C into the nucleus, but not its cleavage and transport, depends on Wingless signaling. We conclude that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535279/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535279/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathew, Dennis -- Ataman, Bulent -- Chen, Jinyun -- Zhang, Yali -- Cumberledge, Susan -- Budnik, Vivian -- GM R01 HD36000/GM/NIGMS NIH HHS/ -- R01 MH070000/MH/NIMH NIH HHS/ -- R01 MH70000/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 25;310(5752):1344-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16311339" target="_blank"〉PubMed〈/a〉
Keywords:
Active Transport, Cell Nucleus
;
Amino Acid Sequence
;
Animals
;
Cell Line
;
Cell Nucleus/*metabolism
;
Drosophila Proteins/chemistry/genetics/*metabolism
;
Drosophila melanogaster/genetics/*metabolism
;
Endocytosis
;
Frizzled Receptors
;
Molecular Sequence Data
;
Muscle Cells/metabolism
;
Mutagenesis, Site-Directed
;
Neuromuscular Junction/*metabolism
;
Protein Binding
;
Proto-Oncogene Proteins/*metabolism
;
Receptors, G-Protein-Coupled
;
Receptors, Neurotransmitter/chemistry/genetics/*metabolism
;
*Signal Transduction
;
Synaptic Membranes/metabolism
;
Transfection
;
Transgenes
;
Wnt1 Protein
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
