Publication Date:
2005-11-08
Description:
Sensory maps in neocortex are adaptively altered to reflect recent experience and learning. In somatosensory cortex, distinct patterns of sensory use or disuse elicit multiple, functionally distinct forms of map plasticity. Diverse approaches-genetics, synaptic and in vivo physiology, optical imaging, and ultrastructural analysis-suggest a distributed model in which plasticity occurs at multiple sites in the cortical circuit with multiple cellular/synaptic mechanisms and multiple likely learning rules for plasticity. This view contrasts with the classical model in which the map plasticity reflects a single Hebbian process acting at a small set of cortical synapses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Feldman, Daniel E -- Brecht, Michael -- R01 NS046652/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2005 Nov 4;310(5749):810-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, Room 0357, La Jolla, CA 92093, USA. dfeldman@ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16272113" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Axons/physiology
;
Brain Mapping
;
Dendrites/physiology
;
Humans
;
Models, Neurological
;
Neural Pathways/physiology
;
*Neuronal Plasticity
;
Neurons/physiology
;
Somatosensory Cortex/growth & development/*physiology
;
Synapses/*physiology
;
Vibrissae/innervation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
